Development of Environmentally Benign Oxidations Using Hypervalent Iodine (III)Reagents
نویسندگان
چکیده
منابع مشابه
Electrophilic alkynylation of ketones using hypervalent iodine.
A new method for the electrophilic α-alkynylation of ketones was developed using hypervalent iodine under mild and metal-free conditions. Carbonyl compounds containing an α-acetylene group were obtained in good to excellent yields for several ketones using 1-[(trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TMS-EBX) as an alkynylation agent in the presence of t-BuOK and TBAF in THF as solven...
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The in situ generated μ-oxo-bridged reactive hypervalent iodine(iii) species 1 or their analogues are introduced as more efficient organocatalysts for the catalytic strategy for realizing practical and greener oxidations.
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Aromatic substituents migrate in a novel oxidative cyclization mediated by iodine(III) reagents. 4-Arylbut-3-enoic acids are cyclized and rearranged to 4-arylfuran-2(5H)-ones by hypervalent iodine compounds in good to excellent yields under mild reaction conditions. Other ring sizes are also accessible. The mechanism of the reaction is described in detail, and calculations highlight the cationi...
متن کاملAlkynylation of heterocyclic compounds using hypervalent iodine reagent.
The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.
متن کاملTotal synthesis of natural products using hypervalent iodine reagents
We present a review of natural product syntheses accomplished in our laboratory during the last 5 years. Each synthetic route features a phenol dearomatization promoted by an environmentally benign hypervalent iodine reagent. The dearomatizations demonstrate the "aromatic ring umpolung" concept, and involve stereoselective remodeling of the inert unsaturations of a phenol into a highly function...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2006
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.126.757